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https://thjbiotech-com-cn.atjbb.com/cn/gongsixinwen zh-hans https://thjbiotech-com-cn.atjbb.com/cn/node/152 <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--newscenter.html.twig x field--node--title.html.twig * field--node--newscenter.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/field/field--node--title.html.twig' --> <span>ACE2-CHO细胞模型助您轻松抗击疫情</span> <!-- END OUTPUT from 'core/themes/stable/templates/field/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--newscenter.html.twig x field--node--uid.html.twig * field--node--newscenter.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/field/field--node--uid.html.twig' --> <span> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/user/username.html.twig' --> <span lang="" about="/cn/user/10" typeof="schema:Person" property="schema:name" datatype="">tjmanager</span> <!-- END OUTPUT from 'core/themes/stable/templates/user/username.html.twig' --> </span> <!-- END OUTPUT from 'core/themes/stable/templates/field/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--newscenter.html.twig x field--node--created.html.twig * field--node--newscenter.html.twig * field--created.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/field/field--node--created.html.twig' --> <span>周三, 03/04/2020 - 09:31</span> <!-- END OUTPUT from 'core/themes/stable/templates/field/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: * links--node.html.twig x links.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/navigation/links.html.twig' --> <!-- END OUTPUT from 'core/themes/stable/templates/navigation/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-newscategory--newscenter.html.twig * field--node--field-newscategory.html.twig * field--node--newscenter.html.twig * field--field-newscategory.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/field/field.html.twig' --> <div> <div>newscategory</div> <div><a href="/cn/gongsixinwen" hreflang="zh-hans">公司新闻</a></div> </div> <!-- END OUTPUT from 'core/themes/stable/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--body--newscenter.html.twig * field--node--body.html.twig * field--node--newscenter.html.twig * field--body.html.twig * field--text-with-summary.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/field/field.html.twig' --> <div><h3><span><span><span><span><span>            新型冠状病毒</span></span><span><span>COVID-19</span></span><span><span>的传染爆发，已经演变成了全球</span></span><span><span>疫情</span></span><span><span>。国际病毒分类委员会已将这个新型冠状病毒命名为“SARS-CoV-2”（原名：2019-nCov），并认定是SARS的“姊妹病毒”。SARS和COVID-19有个共同的“爱好”：喜欢在同一个门破门而入，而这个“门”就是被感染细胞表面上的受体 - 血管紧张素转化酶2 (</span></span><span><span>Angiotensin-converting enzyme 2，ACE2</span></span><span><span>)。</span></span></span></span></span></h3> <p> </p> <img alt="ACE2" data-entity-type="file" data-entity-uuid="f0758f09-075d-4ceb-8bc9-578237655c54" src="/sites/default/files/inline-images/AEC2.jpg" class="align-center" /> <p><span><span><span><span><span>       </span></span></span></span></span></p> <h3><span><span><span><span><span>       ACE2到底是什么呢？在COVID-19的感染和疾病发生上又起到怎样的作用呢？</span></span></span></span></span></h3> <p> </p> <h3><span><span><span><span><span>       ACE2是一种含锌的金属蛋白酶，能够将血管紧张素I</span></span><span><span>(angiotensin I, Ang I)</span></span><span><span>水解成Ang1-9，将血管紧张素II（angiotensin II, Ang II</span></span><span><span>）</span></span><span><span>水解成有血管舒张作用的Ang1-7。根据ACE2基因的器官和细胞特异性表达的特点，推测ACE2可能在调节心血管和肾脏功能以及生育能力中发挥作用。</span></span></span></span></span></h3> <p> </p> <h3><span><span><span><span><span>       研究表明，ACE2主要在肺泡上皮细胞和小肠上皮细胞表达，也在血管内皮细胞和动脉平滑肌细胞表达，还存在于表皮的基底细胞层中。</span></span></span></span></span></h3> <p> </p> <h3><span><span><span><span><span>        ACE2免疫染色研究表明，ACE2主要定位在心脏、肾脏和睾丸中，在其它多种组织中低水平表达。 ACE2已被鉴定为重症急性呼吸综合征（Severe acute respiratory syndrome，SARS）冠状病毒（SARS-CoV）和人CoV-NL63冠状病毒的受体。ACE2通常定位于上皮细胞的腔面，当SARS冠状病毒通过表达ACE2的细胞腔面进行感染时，其感染效力会提高10倍。</span></span></span></span></span></h3> <p> </p> <img alt="ACE2-2" data-entity-type="file" data-entity-uuid="6621bb56-c321-46e0-b3af-98f990957fe9" src="/sites/default/files/inline-images/ACE2-3.jpg" class="align-center" /> <p> </p> <h3><span><span><span><span><span>        大量的研究已经充分表明了ACE2在SARS感染发病过程中所扮演得重要角色。已有的研究证实了</span></span><span><span>COVID-19</span></span><span><span>病毒也是通过ACE2来感染人肺泡上皮细胞的，其致病机理与2002-2003年的SARS具有较高的类似性，因此研究ACE2受体与COVID-19病毒的作用机理，对研发治疗COVID-19病毒感染的疾病的药物和疫苗，就具有了极其重要的意义。</span></span></span></span></span></h3> <p> </p> <h3><span><span><span><span><span>        泰和健公司已积极投身于此次COVID-19病毒感染疫情的抗击战役中，冀望以雄厚的技术实力和研发能力，为扑灭疫情</span></span><span><span>贡献力量。</span></span><span><span>我们已经采用专有的Toggle-In 技术，将人源ACE2定点整合进入CHO细胞的染色体上，形成在细胞表面稳定表达ACE2的细胞模型，ACE2-CHO，为客户深入研究受体ACE2与</span></span><span><span>COVID-19</span></span><span><span>病毒的相互作用，阐释病毒入侵机制，开发治疗</span></span><span><span>COVID-19</span></span><span><span>病毒的药物和疫苗，提供有效的工具。欢迎</span></span><span><span>前来咨询</span></span><span><span>。</span></span></span></span></span></h3> <h3> </h3> <img alt="ACE2-3" data-entity-type="file" data-entity-uuid="69f63ea3-ef46-4058-a3fd-d7551c1dc23c" src="/sites/default/files/inline-images/ACE2-2.jpg" class="align-center" /> <p> </p> <h3><span><span><span><span><span>         此外，泰和健公司正在开发并很快推出‘能在细胞表面稳定表达</span></span><span><span>COVID-19</span></span><span><span>病毒的Spike Protein的’CHO 细胞模型，</span></span><span><span>SP-CHO</span></span><span><span>，敬请期待和预定。</span></span></span></span></span></h3> <h3><span><span><span> </span></span></span></h3> <h3><span><span><span><span><span>Toggle In 方法快速制备细胞株 具有以下优势：</span></span></span></span></span></h3> <p> </p> <h3><span><span><span><span><span>（1）高表达位点的定点整合： </span></span></span></span></span></h3> <h3><span><span><span><span><span>在CHO细胞基因组中预先找到高表达“热点”，采用Cre-LoxP同源重组方法定点整合，因染色体结构开放而始终恒定表达。</span></span></span></span></span></h3> <p> </p> <h3><span><span><span><span><span>（2）按特定比例（Stoichiometry）同时表达多个基因： </span></span></span></span></span></h3> <h3><span><span><span><span><span>外源基因克隆在pTOG3和pTOG4载体中，通过连续无上限打靶，每次都将外源基因整合到指定高表达热点。外源基因的表达比例完全可控。</span></span></span></span></span></h3> <p> </p> <h3><span><span><span><span><span>（3）仅仅需要2个抗生素筛选基因，循环使用，无上限。</span></span></span></span></span></h3> <p> </p> <h3><span><span><span><span><span>（4）近乎100%打靶效率，2周筛选后，细胞池即可用。 </span></span></span></span></span></h3> <h3> </h3> <h3><span><span><span><span><span>有意者可关注微信获取更多信息，也可随时与我公司联系，我们将倾情为您服务！</span></span></span></span></span></h3> <p> </p> <h3><span><span><span><span><span><span>♥</span></span></span><span><span> 联系电话：010-56315224</span></span></span></span></span></h3> <h3><span><span><span><span><span><span>♥</span></span></span> <span><span>联系邮箱：</span></span><a href="mailto:sales@THJBiotech.com"><span><span>Sales@THJBiotech.com</span></span></a></span></span></span></h3> <h3> </h3> <h3><span><span><span><span><span>让我们携起手来，打赢疫情防控阻击战，让春暖花开的日子早日到来！</span></span></span></span></span></h3> <p> </p> <img alt="二维码" data-entity-type="file" data-entity-uuid="0ff93d4e-4703-43a9-abeb-0a90fd45270d" src="/sites/default/files/inline-images/%E4%BA%8C%E7%BB%B4%E7%A0%81.gif" class="align-center" /> <p> </p></div> <!-- END OUTPUT from 'core/themes/stable/templates/field/field.html.twig' --> Wed, 04 Mar 2020 01:31:47 +0000 tjmanager 152 at https://thjbiotech-com-cn.atjbb.com